Szoptatás és légzőszervi betegségek

Protective effect of exclusive breastfeeding against infections during infancy: a prospective study

Ladomenou F, Moschandreas J, Kafatos A, Tselentis Y, Galanakis E.

Arch Dis Child. 2010 Sep 27. [Epub ahead of print]

Abstract

Objective To prospectively investigate the effects of breastfeeding on the frequency and severity of infections in a well-defined infant population with adequate vaccination coverage and healthcare standards.

Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy

Duijts L, Jaddoe VW, Hofman A, Moll HA.
Pediatrics. 2010 Jun 21. [Epub ahead of print]

Abstract

Objective: To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy.

International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life

Garcia-Marcos L, Mallol J, Solé D, Brand PL; the EISL Study Group.
Pediatr Allergy Immunol. 2010 Apr 27. [Epub ahead of print]

Abstract

Risk factors for wheezing during the first year of life (a major cause of respiratory morbidity worldwide) are poorly known in non-affluent countries. We studied and compared risk factors in infants living in affluent and non-affluent areas of the world. A population-based study was carried out in random samples of infants from centres in Latin America (LA) and Europe (EU).

Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6.

Sabirov A, Casey JR, Murphy TF, Pichichero ME.
Pediatr Res. 2009 Nov;66(5):565-70.

Abstract

Nontypeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in infants. Breast-feeding protects against AOM and/or nasopharyngeal (NP) colonization; however, the mechanism of protection is incompletely understood. Children with AOM and healthy children were studied according to feeding status: breastfed,breast/formula fed, or formula fed.

Breastfeeding protects against infectious diseases during infancy in industrialized countries. A systematic review

Liesbeth Duijts, Made K. Ramadhani and Henriëtte A. Moll
Maternal & Child Nutrition Volume 5 Issue 3, Pages 199 - 210; 2009

Abstract

Firstly, this review was performed to assess the effect of breastfeeding on infections during infancy in industrialized countries. Secondly, the effect of duration and exclusiveness of breastfeeding were explored.

Differential Gender Response to Respiratory Infections and to the Protective Effect of Breast Milk in Preterm Infants

M. Inés Klein, MD, Eduardo Bergel, PhD, Luz Gibbons, PhD, Silvina Coviello, MS, Gabriela Bauer, MD, Alicia Benitez, MD, M. Elina Serra, MD, M. Florencia Delgado, MS, Guillermina A. Melendi, MD, Susana Rodríguez, MD, Steven R. Kleeberger, PhD and Fernando P. Polack, MD

PEDIATRICS Vol. 121 No. 6 June 2008, pp. e1510-e1516

Abstract

OBJECTIVE. The protective role of breastfeeding against severe acute lung disease in infants is well established, but its mechanism is unclear. Most hypotheses assume that breastfeeding confers similar passive protection to every infant; however, a few observations have suggested that the benefits of breast milk against severe lung disease may differ according to gender. The objective of this study was to determine whether the effect of breastfeeding on susceptibility to severe acute lung disease among infants at high risk is different for girls and boys.

Immunomodulatory constituents of human milk change in response to infant bronchiolitis

Dani-Louise Bryan, Prue H. Hart, Kevin D. Forsyth, Robert A. Gibson (2007)
Pediatric Allergy and Immunology 18 (6), 495–502

Abstract

Although epidemiological evidence is generally supportive of a causal association between respiratory syncytial virus (RSV) bronchiolitis during infancy and the development of persistent wheeze/asthma, if not allergy, the mechanism by which this occurs and an explanation for why all children do not succumb remains to be elucidated. Breast feeding has been found to confer a protective effect against respiratory infections such as RSV bronchiolitis and allergy; however, again there is little direct evidence and no clear mechanism. In this study, we examined whether human milk immunomodulatory factors (cells, cytokines) change in response to clinically diagnosed, severe bronchiolitis in the recipient breast-fed infant.

Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries

Stanley Ip, M.D., Mei Chung, M.P.H., Gowri Raman, M.D., Priscilla Chew, M.P.H., Nombulelo Magula, M.D., Deirdre DeVine, M.Litt., Thomas Trikalinos, M.D., Ph.D., Joseph Lau, M.D.

Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, April 2007

Structured Abstract

Objectives: We reviewed the evidence on the effects of breastfeeding on short- and long-term infant and maternal health outcomes in developed countries.

Data Sources: We searched MEDLINE®, CINAHL, and the Cochrane Library in November of 2005. Supplemental searches on selected outcomes were searched through May of 2006. We also identified additional studies in bibliographies of selected reviews and by suggestions from technical experts.

Breastfeeding and Hospitalization for Diarrheal and Respiratory Infection in the United Kingdom Millennium Cohort Study

Maria A. Quigley, MSc, Yvonne J. Kelly, PhD and Amanda Sacker, PhDb

PEDIATRICS Vol. 119 No. 4 April 2007, pp. e837-e842

Abstract

OBJECTIVE. The objective of this study was to measure the effect of breastfeeding on hospitalization for diarrheal and lower respiratory tract infections in the first 8 months after birth in contemporary United Kingdom.

Full Breastfeeding and Hospitalization as a Result of Infections in the First Year of Life

José María Paricio Talayero, MD, PhD, Máxima Lizán-García, MD, PhD, Ángel Otero Puime, MD, PhD, María José Benlloch Muncharaz, MD, Beatriz Beseler Soto, MD, Marta Sánchez-Palomares, MD, Luis Santos Serrano, MD and Leonardo Landa Rivera, MD

PEDIATRICS Vol. 118 No. 1 July 2006, pp. e92-e99

ABSTRACT

OBJECTIVE. Our objective was to assess the effect of breastfeeding on the probability of hospitalization as a result of infectious processes during the first year of life.

METHODS. We followed 1385 infants from birth to age 1 year between 1996 and 1999. Recruitment and data collection were done at the 6-month well-infant visit under the National Child Health Program. Full breastfeeding, hospital admission, and other relevant variables related to the delivery, infant, mother, health services system, and sociologic aspects were recorded. The statistical analysis included Kaplan-Meier test, Cox regression to obtain the hazard ratio, and the adjusted attributable risk.

Full Breastfeeding Duration and Associated Decrease in Respiratory Tract Infection in US Children

Caroline J. Chantry, MD, Cynthia R. Howard, MD, MPH and Peggy Auinger, MS

PEDIATRICS Vol. 117 No. 2 February 2006, pp. 425-432

OBJECTIVE. The American Academy of Pediatrics recommends exclusive breastfeeding for an infant's first 6 months of life. When compared with exclusive breastfeeding for 4 months, greater protection against gastrointestinal infection, but not respiratory tract infection, has been demonstrated for the 6-month duration. The objective of this study was to ascertain if full breastfeeding of ≥6 months compared with 4 to < 6 months in the United States provides greater protection against respiratory tract infection.

Breast feeding and respiratory morbidity in infancy: a birth cohort study

Aim: To examine the relation between the duration of breast feeding and morbidity as a result of respiratory illness and infection in the first year of life.
Archives of Disease in Childhood 2003;88:224-228

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Exclusive Breastfeeding Protects Against Bacterial Colonization and Day Care Exposure to Otitis Media

Objective. We followed a cohort (N = 306) of infants at well-baby visits in two suburban pediatric practices to assess the relation of exclusive breastfeeding, and other environmental exposures, to episodes of acute otitis media (AOM) and otitis media with effusion (OME).
PEDIATRICS Vol. 100 No. 4 October 1997, p. e7

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TGF-β in human milk is associated with wheeze in infancy

Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL.
J Allergy Clin Immunol. 2003 Oct;112(4):723-8.

Abstract

BACKGROUND: Cytokines secreted in human milk might play important roles in newborn health and in the development of infant immune responses. We investigated the relationship of the concentration and dose of cytokines in human milk to infant wheeze at 1 year of age.

OBJECTIVE: Our objective was to test whether the cytokines in milk could account for some of the apparent protective effect of breast-feeding against wheeze in the first year of life.

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