Szoptatás és gyomor-bélrendszeri betegségek

Protective effect of exclusive breastfeeding against infections during infancy: a prospective study

Ladomenou F, Moschandreas J, Kafatos A, Tselentis Y, Galanakis E.

Arch Dis Child. 2010 Sep 27. [Epub ahead of print]

Abstract

Objective To prospectively investigate the effects of breastfeeding on the frequency and severity of infections in a well-defined infant population with adequate vaccination coverage and healthcare standards.

Chronic disease and infant nutrition: is it significant to public health?

Smith JP, Harvey PJ.
Public Health Nutr. 2010 Jul 13:1-11.

Abstract

OBJECTIVE: To assess the public health significance of premature weaning of infants from breast milk on later-life risk of chronic illness.

Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy

Duijts L, Jaddoe VW, Hofman A, Moll HA.
Pediatrics. 2010 Jun 21. [Epub ahead of print]

Abstract

Objective: To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy.

Population-based cases control study of inflammatory bowel disease risk factors.

Gearry RB, Richardson AK, Frampton CM, Dodgshun AJ, Barclay ML.
J Gastroenterol Hepatol. 2010 Jan 14. [Epub ahead of print]

Abstract

Background and Aim: The rapid increase in inflammatory bowel disease (IBD) incidence confirms the importance of environment in its etiology. We aimed to assess the role of childhood and other environmental risk factors in IBD.

An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products

Sullivan S, Schanler RJ, Kim JH, Patel AL, Trawöger R, Kiechl-Kohlendorfer U, Chan GM, Blanco CL, Abrams S, Cotten CM, Laroia N, Ehrenkranz RA, Dudell G, Cristofalo EA, Meier P, Lee ML, Rechtman DJ, Lucas A.
J Pediatr. 2009 Dec 24. [Epub ahead of print]

Abstract

Objective To evaluate the health benefits of an exclusively human milk–based diet compared with a diet of both human milk and bovine milk–based products in extremely premature infants.

Protection of the Neonate by the Innate Immune System of Developing Gut and of Human Milk

Newburg, DS.; Walker, WA.
Pediatr Res 61: 2–8, 2007

Abstract

The neonatal adaptive immune system, relatively naïve to foreign antigens, requires synergy with the innate immune system to protect the intestine. Goblet cells provide mucins, Paneth cells produce antimicrobial peptides, and dendritic cells (DCs) present luminal antigens. Intracellular signaling by Toll-like receptors (TLRs) elicits chemokines and cytokines that modulate inflammation. Enteric neurons and lymphocytes provide paracrine and endocrine signaling. However, full protection requires human milk. Breast-feeding reduces enteric infection and may reduce chronic disease in later life. Although human milk contains significant secretory immunoglobulin A (sIgA), most of its protective factors are constitutively expressed. Multifunctional milk components are nutrients whose partial digestion products inhibit pathogens. Cytokines, cytokine receptors, TLR agonists and antagonists, hormones, anti-inflammatory agents, and nucleotides in milk modulate inflammation.

Breastfeeding protects against infectious diseases during infancy in industrialized countries. A systematic review

Liesbeth Duijts, Made K. Ramadhani and Henriëtte A. Moll
Maternal & Child Nutrition Volume 5 Issue 3, Pages 199 - 210; 2009

Abstract

Firstly, this review was performed to assess the effect of breastfeeding on infections during infancy in industrialized countries. Secondly, the effect of duration and exclusiveness of breastfeeding were explored.

Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children

Theresa A Mikhailov, Sylvia E Furner
World J Gastroenterol. 2009 Jan 21;15(3):270-9.

Abstract

Inflammatory bowel disease is a chronic, debilitating disorder of the gastrointestinal tract. The etiology of inflammatory bowel disease has not been elucidated, but is thought to be multifactorial with both environ-mental and genetic influences.

Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death

J Meinzen-Derr, B Poindexter, L Wrage, A L Morrow, B Stoll and E F Donovan

Journal of Perinatology (2009) 29, 57–62

Objective: To determine the association between human milk (HM) intake and risk of necrotizing enterocolitis (NEC) or death among infants 401 to 1000 g birth weight.

Maternal Antibodies in Breast Milk Protect the Child From Enterovirus Infections

Karita Sadeharju, MD, PhD, Mikael Knip, MD, PhD, Suvi M. Virtanen, MD, PhD, Erkki Savilahti, MD, PhD, Sisko Tauriainen, PhD, Pentti Koskela, MD, PhD, Hans K. Åkerblom, MD, PhD, Heikki Hyöty, MD, PhD and and the Finnish TRIGR Study Group

PEDIATRICS Vol. 119 No. 5 May 2007, pp. 941-946

Abstract

OBJECTIVE. Enterovirus infections are frequent in infants and may cause severe complications. We set out to assess whether breastfeeding can protect against these infections and whether such an effect is related to maternal antibodies in breast milk or in the peripheral circulation of the infant.

Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries

Stanley Ip, M.D., Mei Chung, M.P.H., Gowri Raman, M.D., Priscilla Chew, M.P.H., Nombulelo Magula, M.D., Deirdre DeVine, M.Litt., Thomas Trikalinos, M.D., Ph.D., Joseph Lau, M.D.

Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, April 2007

Structured Abstract

Objectives: We reviewed the evidence on the effects of breastfeeding on short- and long-term infant and maternal health outcomes in developed countries.

Data Sources: We searched MEDLINE®, CINAHL, and the Cochrane Library in November of 2005. Supplemental searches on selected outcomes were searched through May of 2006. We also identified additional studies in bibliographies of selected reviews and by suggestions from technical experts.

Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants

P M Sisk, C A Lovelady, R G Dillard, K J Gruber and T M O'Shea

Journal of Perinatology (2007) 27, 428–433; published online 19 April 2007

Abstract

Background: Necrotizing enterocolitis (NEC) is a frequent cause of mortality and morbidity in very low birth weight (VLBW) infants. Human milk (HM) feeding has been associated with lower risk of NEC. However, mothers of VLBW infants often experience insufficient milk production, resulting in mixed feedings of HM and formula. Moreover, medical complications often limit the volume of feeding they can be given.

Objective: To determine if high proportions of (50% or greater) HM enteral feeding within the first 14 days of life are protective against NEC.

Breastfeeding and Hospitalization for Diarrheal and Respiratory Infection in the United Kingdom Millennium Cohort Study

Maria A. Quigley, MSc, Yvonne J. Kelly, PhD and Amanda Sacker, PhDb

PEDIATRICS Vol. 119 No. 4 April 2007, pp. e837-e842

Abstract

OBJECTIVE. The objective of this study was to measure the effect of breastfeeding on hospitalization for diarrheal and lower respiratory tract infections in the first 8 months after birth in contemporary United Kingdom.

Full Breastfeeding and Hospitalization as a Result of Infections in the First Year of Life

José María Paricio Talayero, MD, PhD, Máxima Lizán-García, MD, PhD, Ángel Otero Puime, MD, PhD, María José Benlloch Muncharaz, MD, Beatriz Beseler Soto, MD, Marta Sánchez-Palomares, MD, Luis Santos Serrano, MD and Leonardo Landa Rivera, MD

PEDIATRICS Vol. 118 No. 1 July 2006, pp. e92-e99

ABSTRACT

OBJECTIVE. Our objective was to assess the effect of breastfeeding on the probability of hospitalization as a result of infectious processes during the first year of life.

METHODS. We followed 1385 infants from birth to age 1 year between 1996 and 1999. Recruitment and data collection were done at the 6-month well-infant visit under the National Child Health Program. Full breastfeeding, hospital admission, and other relevant variables related to the delivery, infant, mother, health services system, and sociologic aspects were recorded. The statistical analysis included Kaplan-Meier test, Cox regression to obtain the hazard ratio, and the adjusted attributable risk.

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