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Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group.
Neurology. 2010 Nov 30;75(22):1954-60.

Abstract

BACKGROUND: Breastfeeding is known to have beneficial effects, but there is concern that breastfeeding during antiepileptic drug (AED) therapy may be harmful to cognitive development. Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children.

D. Jeffrey Newport, Page B. Pennell, Martha R. Calamaras, James C. Ritchie, Melanee Newman, Bettina Knight, Adele C. Viguera, Joyce Liporace and Zachary N. Stowe

PEDIATRICS Vol. 122 No. 1 July 2008, pp. e223-e231

Abstract

OBJECTIVE. Although lamotrigine use during pregnancy has substantially increased over the past decade secondary to accumulated reproductive safety data, systematic data on lamotrigine during breastfeeding remains sparse. We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma.