Adele C. Viguera, M.D., M.P.H., D. Jeffrey Newport, M.D., James Ritchie, Ph.D., Zachary Stowe, M.D., Theodore Whitfield, Sc.D., Juliana Mogielnicki, B.A., Ross J. Baldessarini, M.D., Amanda Zurick, B.A. and Lee S. Cohen, M.D.
Am J Psychiatry 164:342-345, February 2007
OBJECTIVE: Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants.
METHOD: In 10 mother-infant pairs, the authors obtained assays of lithium in maternal serum, breast milk, and infant serum and indices of infant renal and thyroid function.
Evelyn T. Rubin, Amy Lee, Shinya Ito
Can J Clin Pharmacol Vol 11(2) Fall 2004: e257-e266;
Background Breastfeeding is the ideal method of infant nutrition. However, if mothers need medications such as the central nervous system (CNS) acting drugs, infant safety concerns arise. Summarized information on infant exposure levels to drugs in milk and associated side effect profiles will help clinicians to rationalize and justify important drug therapy for a breastfeeding patient.