Szoptatás Portál ... naprakész információk a szoptatásról

Miranda So, Pina Bozzo, Miho Inoue and Adrienne Einarson
Can Fam Physician Vol. 56, No. 5, May 2010, pp.427 - 429

QUESTION Many of my pregnant and breastfeeding patients suffer from allergies and frequently ask me about the safety of antihistamines during pregnancy and breastfeeding. Should I advise them to use the older sedating medications? I have heard that they might be safer than the newer nonsedating class of drugs. Or have the newer ones been studied as well?

J Hilbert, E Radwanski, MB Affrime, G Perentesis, S Symchowicz, and N Zampaglione

The Journal of Clinical Pharmacology, 1988; 28:234-239

(A loratadine Magyarországon Clarinase, Claritine, Erolin, Flonidan, Lorano, Loratadin, Roletra neveken van forgalomban.)

The excretion of loratadine, a new nonsedating antihistamine, into human breast milk was studied in six lactating nonpregnant volunteers. Each volunteer received one 40-mg loratadine capsule. Milk and blood were collected before and at specified times (to 48 hours) after dosing. Plasma and milk loratadine concentrations were determined by a specific radioimmunoassay, and those of an active but minor metabolite, descarboethoxyloratadine, by high performance liquid chromatography (HPLC).